[Integrated molecular targeting, capturing and storage technology]

Inspire

ZipPrime offers an all-in-one solution to capture, detect and preserve the rare and fragile circulating free DNA (cfDNA) molecules at a single molecule level. ZipPrime’s solution improves the accuracy and reproducibility of cfDNA-based assays by capturing and tagging even a single copy of cfDNA molecule.

[Unleash the potential of Your DNA]

[Low abundance and fragility of biomarkers derived from circulating free DNA fragments]

Challange of cfDNAs

Reliable early detection of cancer has potential to dramatically decrease global cancer mortality. Liquid biopsy is a non-invasive technique that enables to detect and to monitor cancer biomarkers in blood, urine and other body fluids at an early stage, even before symptoms appear. One of most valuable biomarker used in LB is cfDNA molecules, the extracellular DNA floating freely in the blood circulation. ccfDNA fragments are released from both healthy and tumour cells through various cell physiological events such as apoptosis, necrosis, and secretion. Although LB is progressing into an advanced and invaluable tool in cancer diagnostics, today the implementation of cfDNA biomarker-based early cancer diagnostic tests is extremely challenging because of the irreversible loss of ccfDNA biomarkers due to the inefficiency of pre-analytical workflow and commercial ccfDNA sample preparation kits.

[Overcome the accuracy, reproducibility and preservation challenges of circulating free DNA assays]

[Platform independent, cost effective all-in-one solution for clinicians and researchers]

Novel Solution

Inspired from intracellular DNA recognition pathways, ZipPrime has developed and patented and novel cfDNA capturing and preservation technology that prevents the loss of cfDNAs and improves the accuracy of cfDNA-based clinical diagnosis by tagging each and every cfDNA biomarker at a single molecule level.

ZipPrime offers standardized, highly-efficient and high-quality cfDNA sample preparation kits enabling sensitive cfDNA biomarker detection. ZipPrime’s cfDNA sample preparation kit enables the capturing and tagging even a single copy of cfDNA molecule from liquid biopsies in a re-usable manner and to detect and preserve each and every cfDNA biomarker. This simple, elegant, accurate and low cost solution can also be used with any PCR-based protocol including multiplex PCR, qPCR, microarrays and Next-Generation Sequencing (NGS) whenever required, even after long-term storage.

[One complete solution to capture, to detect and to preserve the rare and fragile circulating free DNA molecules]